2024

Boutonnet M, Carpena C, Bouquier N, Chastagnier Y, Font-Ingles J, Moutin E, Tricoire L, Chemin J, Perroy J (2024). Voltage tunes mGlu5 receptor function, impacting synaptic transmission. Br J Pharmacol. Feb 18. doi: 10.1111/bph.16317.

Dumazer A, Gómez-Santacana X, Malhaire F, Jopling C, Maurel D, Lebon G, Llebaria A, Goudet C (2024). Optical Control of Adenosine A2A Receptor Using Istradefylline Photosensitivity. ACS Chem Neurosci. 2024 Feb 7;15(3):645-655. doi: 10.1021/acschemneuro.3c00721.

Haubrich J, Zwier JM, Charrier-Savournin F, Prézeau L, Pin JP. Different EGF-induced receptor dimer conformations for signaling and internalization (2024). FASEB J. Jan;38(1):e23356. doi: 10.1096/fj.202301209R.

2023

Lecat-Guillet N, Quast RB, Liu H, Bourrier E, Møller TC, Rovira X, Soldevila S, Lamarque L, Trinquet E, Liu J, Pin JP, Rondard P, Margeat E. (2023). Concerted conformational changes control metabotropic glutamate receptor activity. Sci Adv. 2023 Jun 2; 9(22): eadf1378. doi: 10.1126/sciadv.adf1378

2022

Kampen S, Rodríguez D, Jørgensen M, Kruszyk-Kujawa M, Huang X, Collins M, Boyle N, Maurel D, Rudling A, Lebon G, and Carlsson J (2022). Structure-Based Discovery of Negative Allosteric Modulators of the 2 Metabotropic Glutamate Receptor 5. ACS Chem Biol. DOI: 10.1021/acschembio.2c00234

Liu J, Hengmin Tang, Xu C, Zhou S, Zhu X, Li Y, Prézeau L, Xu T, Pin JP, Rondard P, Ji W, Liu J (2022). Biased signaling due to oligomerization of the G protein-coupled platelet-activating factor receptor. Nat Commun. 2022; 13: 6365. doi: 10.1038/s41467-022-34056-4

Gazdarica M, Noda J, Durydivka O, Novosadova V, Mackie K, Pin JP, Prezeau L, Blahos J. (2022). SGIP1 modulates kinetics and interactions of the cannabinoid receptor 1 and G protein‐coupled receptor kinase 3 signalosome. J Neurochem. 2022 Mar; 160(6): 625–642. doi: 10.1111/jnc.15569

A. Mills, N. Aissaoui, D. Maurel, J. Elezgaray, F. Morvan, J. J. Vasseur, E. Margeat, R. B. Quast, J. Lai Kee-Him, N. Saint, C. Benistant, A. Nord, F. Pedaci, G. Bellot (2022). A modular spring-loaded actuator for mechanical activation of membrane proteins. Nature Com. DOI: 10.1038/s41467-022-30745-2

Meng J, Xu C, Lafon PA, Roux S, Mathieu M, Zhou R, Scholler P, Blanc E, Becker J, Le Merrer J, González-Maeso J, Chames P, Liu J, Pin Jp, Rondard P (2022). Nanobody-based sensors reveal a high proportion of mGlu heterodimers in the brain. Nat Chem Biol. DOI: 10.1038/s41589-022-01050-2

Bous  J, Fouillen  A, Orcel  H , Trapani  S , Cong  X, Fontanel  S , Saint-Paul  J, Lai-Kee-Him  J, Urbach  S, Sibille  N, Sounier  R, Granier  S, Mouillac B, Bron  P (2022). Structure of the vasopressin hormone-V2 receptor-β-arrestin1 ternary complex. Sci Adv. DOI: 10.1126/sciadv.abo7761

2021

Cong X, Maurel D, Déméné H, Vasiliauskaité-Brooks I, Hagelberger J, PeyssonF, Saint-Paul J, Golebiowski J, Granier S, Sounier R (2021). Molecular insights into the biased signaling mechanism of the μ-opioid receptor. Molecular Cell. DOI: 10.1016/j.molcel.2021.07.033

Lemel L, Niescierowicz K, García-Fernandez MD, Darré L, Durroux T, Busnelli, Pezet M, Rébeillé F , Jouhet J, Mouillac B, Domene C, Chini B, Cherezov V and Moreau CJ (2021). The ligand-bound state of a G protein-coupled receptor stabilizes the interaction of functional cholesterol molecules. doi: 10.1016/j.jlr.2021.100059

Grison CM, Lambey P, Jeannot S, Del Nero E, Fontanel S, Peysson F, Heuninck J, Sounier R, Durroux T, Leyrat C, Granier S and Bechara C (2021). Molecular insights into mechanisms of GPCR hijacking by Staphylococcus aureus. PNAS. DOI: 10.1073/pnas.2108856118

Healey RD, Saied EM, Cong X, Karsai G, Gabellier L, Saint Paul J, Del Nero E, Jeannot S, Drapeau M, Fontanel S, Maurel D, Basu S, Leyrat C, Golebiowski J, Bossis G, Bechara C, Hornemann T, Arenz C, Granier S (2021). Discovery and mechanism of action of small molecule inhibitors of ceramidases. Angewandte Chemie. https://doi.org/10.1002/anie.202109967

Haubrich J, Font J, Quast RB, Goupil-Lamy A, Scholler P, Nevoltris D, Acher F, Chames P, Rondard P, Prézeau L, and Pin JP (2021). A nanobody activating metabotropic glutamate receptor 4 discriminates between homo- and heterodimers. PNAS. doi:10.1073/pnas.2105848118

Zindel  D , Mensat P , Vol  C , Homayed  Z , Charrier-Savournin  F , Trinquet  E , Banères  JL, Pin  JP , Pannequin  J , Roux  T , Dupuis  E, Prézeau  L. (2021). G protein-coupled receptors can control the Hippo/YAP pathway through Gq signaling. FASEB J. doi: 10.1096/fj.202002159R.

Nasrallah C, Cannone C, Briot J, Rottier K, Berizzi AE, Huang CY, Quast RB, Hoh F, Banères JL, Malhaire F, Berto L, Dumazer A, Font-Ingles J, Gómez-Santacana X, Catena J, Kniazeff J, Goudet C, Llebaria A, Pin JP, Vinothkumar KR, and Guillaume Lebon. Agonists and allosteric modulators promote signaling from different metabotropic glutamate receptor 5 conformations (2021). Cell Rep. doi: 10.1016/j.celrep.2021.109648

Lemel L, Niescierowicz K, García-Fernandez MD, Darre L , Durroux T, Busnelli M, Pezet M, Rebeille F , Jouhet J, Mouillac B, Domene C, Chini B, Cherezov V, and Moreau CJ (2021). The ligand-bound state of a G protein-coupled receptor stabilizes the interaction of functional cholesterol molecules. J. Lipid Res. https://doi.org/10.1016/j.jlr.2021.100059

Ollivier M, Beudez J, Linck N, Grutter T, Compan V and Rassendren F (2021). P2X-GCaMPs as Versatile Tools for Imaging Extracellular ATP Signaling. eNEURO. https://doi.org/10.1523/ENEURO.0185-20.2020

2020

Gentzsch C, Seier K, Drakopoulos A, Jobin ML, Lanoiselée Y, Koszegi Z, Maurel D, Sounier R, Hübner H, Gmeiner P, Granier S, Calebiro D, Decker M (2019). Selective and Wash‐Resistant Fluorescent Dihydrocodeinone‐Derivatives Allow Single‐Molecule Imaging of mu‐Opioid Receptor Dimerisation. Angewandte Chemie. https://doi.org/10.1002/anie.201912683.

Liu H, Yi  P, Zhao W, Wu Y, Acher F, Pin  JP, Liu J, Rondard P (2020). Illuminating the allosteric modulation of the calcium-sensing receptor. PNAS. DOI: 10.1073/pnas.1922231117

Fumagalli A, Heuninck J, Pizzoccaro A, Moutin E, Koenen J, Séveno M, Durroux T, Marie-Pierre Junier, Géraldine Schlecht-Louf, Francoise Bachelerie, Dagmar Schütz, Ralf Stumm, Martine J. Smit, Nathalie C. Guérineau, Séverine Chaumont-Dubel & Philippe Marin (2020). The atypical chemokine receptor 3 interacts withcConnexin 43 inhibiting astrocytic gap junctional intercellular communication. Nature Comm. DOI : https://doi.org/10.1038/s41467-020-18634-y

Sebastianutto I, Goyet E, Andreoli L, Font-Ingles J, Moreno-Delgado D, Bouquier N, Jahannault-Talignani C, Moutin E, Di Menna L, Maslava N, Pin JP, Fagni L, Nicoletti F, Ango F, Cenci MA, and Perroy J (2020). D1-mGlu5 heteromers mediate noncanonical dopamine signaling in Parkinson’s disease. The Journal of Clinical Investigation. https://doi.org/10.1172/JCI126361

Shaye H, Ishchenko A, Homing Lam J, Won Han G , Xue L, Rondard P, Pin JP, Katritch V, Gati C, and Cherezov.  Structural basis of the activation of a metabotropic GABA receptor (2020). Nature. DOI : 10.1038/s41586-020-2408-4

Moutin E, Hemonnot AL, Seube V, Linck N, Rassendren F, Perroy J and Compan V. Procedures for Culturing and Genetically Manipulating Murine Hippocampal Postnatal Neurons (2020). https://doi.org/10.3389/fnsyn.2020.00019

Cubizolle A, Cia D, Moine E, Jacquemot N, Guillou L, Rosell M, Angebault-Prouteau C, Lenaers G, Meunier I, Vercauteren J, Durand T, Crauste C, Brabet P. Isopropyl-phloroglucinol-DHA protects outer retinal cells against lethal dose of all-trans-retinal (2020). J Cell Mol Med. DOI: 10.1111/jcmm.15135

2019

Zindel D, Vol C, Lecha O, Bequignon I, Bilgic M, Vereecke M, Charrier-Savournin F, Romier M, Trinquet E, Pin JP, Pannequin J, Roux T, Dupuis E, Prézeau L (2019). HTRF® Total and Phospho-YAP (Ser127) Cellular Assays. Methods Mol Biol. 1893:153-166.

Heuninck J, Hounsou C, Dupuis E, Trinquet E, Mouillac B, Pin JP, Bonnet D, Durroux T. Time-Resolved FRET-Based Assays to Characterize G Protein-Coupled Receptor Hetero-oligomer Pharmacology (2019). Methods Mol Biol. 1947:151-168.

Hajj M, De Vita T, Vol C, Renassia C, Bologna JC, Brabet I, Cazade M, Pastore M, Blahos J, Labesse G, Pin JP, Prézeau L (2019). Nonclassical Ligand-Independent Regulation of Go Protein by an Orphan Class C G-Protein–Coupled Receptor. Mol Pharmacol. Aug;96(2):233-246.

2018

Belhocine A, Veglianese P, Hounsou C, Dupuis E, Acher F, Durroux T, Goudet C, Pin JP. Profiling of orthosteric and allosteric group-III metabotropic glutamate receptor ligands on various G protein-coupled receptors with Tag-lite^® assays. Neuropharmacology. 2018;140: 233-245.

Tora AS, Rovira X, Cao AM, Cabayé A, Olofsson L, Malhaire F, Scholler P, Baik H, Van Eeckhaut A, Smolders I, Rondard P, Margeat E, Acher F, Pin JP, Goudet C. Chloride ions stabilize the glutamate-induced active state of the metabotropic glutamate receptor 3. Neuropharmacology. 2018;140: 275-286.

Nasrallah C, Rottier K, Marcellin R, Compan V, Font J, Llebaria A, Pin JP, Banères JL, Lebon G (2018). Direct coupling of detergent purified human mGlu5 receptor to the heterotrimeric G proteins Gq and Gs. Sci Rep. 2018 Mar 13;8(1):4407.

Selvam C, Lemasson IA, Brabet I, Oueslati N, Karaman B, Cabaye A, Tora AS, Commare B, Courtiol T, Cesarini S, McCort-Tranchepain I, Rigault D, Mony L, Bessiron T, McLean H, Leroux FR, Colobert F, Daniel H, Goupil-Lamy A, Bertrand HO, Goudet C, Pin JP, Acher FC (2018). Increased Potency and Selectivity for Group III Metabotropic Glutamate Receptor Agonists Binding at Dual sites. J Med Chem.  Mar 8;61(5):1969-1989.

Stewart GD, Comps-Agrar L, Nørskov-Lauritsen LB, Pin JP, Kniazeff J. Allosteric interactions between GABAB1 subunits control orthosteric binding sites occupancy within GABAB oligomers 2018). Neuropharmacology. Jan 2, S0028-3908(17)30640-8.

2017

Moreno Delgado D, Møller TC, Ster J, Giraldo J, Maurel D, Rovira X, Scholler P, Zwier JM, Perroy J, Durroux T, Trinquet E, Prezeau L, Rondard P, Pin JP (2017). Pharmacological evidence for a metabotropic glutamate receptor heterodimer in neuronal cells. Elife. 29;6.

Lecat-Guillet N, Monnier C, Rovira X, Kniazeff J, Lamarque L, Zwier JM, Trinquet E, Pin JP, Rondard P (2017). FRET-Based Sensors Unravel Activation and Allosteric Modulation of the GABAB Receptor. Cell Chem Biol. 16;24(3):360-370.

Scholler P, Moreno-Delgado D, Lecat-Guillet N, Doumazane E, Monnier C, Charrier-Savournin F, Fabre L, Chouvet C, Soldevila S, Lamarque L, Donsimoni G, Roux T, Zwier JM, Trinquet E, Rondard P, Pin JP (2017). HTS-compatible FRET-based conformational sensors clarify membrane receptor activation. Nat Chem Biol. 13(4):372-380.

Perkovska S, Méjean C, Ayoub MA, Li J, Hemery F, Corbani M, Laguette N, Ventura MA, Orcel H, Durroux T, Mouillac B, Mendre C (2017). V1b vasopressin receptor trafficking and signaling : role of arrestins, G proteins and Src kinase. Traffic. 16.

Duquenne C, Gimenez S, Guigues A, Viala B, Boulouis C, Mettling C, Maurel D, Campos N, Doumazane E, Comps-Agrar L, Tazi J, Prézeau L, Corbeau P, François V (2017). Reversing HIV latency via sphingosine-1-phosphate receptor 1 signaling. AIDS. Sep 18.

2016

Hájková A, Techlovská Š, Dvořáková M, Chambers JN, Kumpošt J, Hubálková P, Prezeau L, Blahos J (2016). SGIP1 alters internalization and modulates signaling of activated cannabinoid receptor 1 in a biased manner. Neuropharmacology. 107:201-214.

Broad J, Maurel D, Kung VWS, Hicks GA, Schemann M, Barnes MR, Kenakin TP, Granier S, Sanger GJ (2016). Human native kappa opioid receptor functions not predicted by recombinant receptors: Implications for drug design. Scientific Reports. 6:30797.

Goyet E, Bouquier N, Ollendorff V, Perroy J (2016). Fast and high resolution single-cell BRET imaging. Scientific Reports 6:28231.

Zussy C, Gómez-Santacana X, Rovira X, De Bundel D, Ferrazzo S, Bosch D, Asede D, Malhaire F, Acher F, Giraldo J, Valjent E, Ehrlich I, Ferraguti F, Pin JP, Llebaria A and Goudet C (2016). Dynamic modulation of inflammatory pain-related affective and sensory symptoms by optical control of amygdala metabotropic glutamate receptor 4. Molecular Psychiatry. 00, 1–12.

2015

Levoye A, Zwier JM, Jaracz-Ros A, Klipfel L, Cottet M, Maurel D, Bdioui S, Balabanian K, Prézeau L, Trinquet E, Durroux T, Bachelerie F (2015). A Broad G Protein-Coupled Receptor Internalization Assay that Combines SNAP-Tag Labeling, Diffusion-Enhanced Resonance Energy Transfer, and a Highly Emissive Terbium Cryptate. Front Endocrinol (Lausanne). 9;6:167.

Zampieri A, Champagne J, Auzemery B, Fuentes I, Maurel B, Bienvenu F (2015). Hyper sensitive protein detection by Tandem-HTRF reveals Cyclin D1 dynamics in adult mouse. Scientific Reports; 5: 15739.

Rovira X, Malhaire F, Scholler P, Rodrigo J, Gonzalez-Bulnes P, Llebaria A, Pin JP, Giraldo J, Goudet C (2015). Overlapping binding sites drive allosteric agonism and positive cooperativity in type 4 metabotropic glutamate receptors. FASEB J; 29(1):116-30.

Hounsou C, Margathe J, Oueslati N, Belhocine A, Dupuis E, Thomas C, Mann A, Ilien B, Rognan D, Trinquet E, Hibert M, Pin JP, Bonnet D, Durroux T (2015). Time-resolved FRET binding assay to investigate hetero-oligomer binding properties: proof of concept with dopamine D1/D3 heterodimer. ACS Chem Biol; 20;10(2):466-74.

Oueslati N, Hounsou C, Belhocine A, Rodriguez T, Dupuis E, Zwier JM, Trinquet E, Pin JP, Durroux T (2015). Time-resolved FRET strategy to screen GPCR ligand library. Methods Mol Biol.; 1272:23-36.

Faklaris O, Cottet M, Falco A, Villier B, Laget M, Zwier JM, Trinquet E, Mouillac B, Pin JP, Durroux T. Multicolor time-resolved Förster resonance energy transfer microscopy reveals the impact of GPCR oligomerization on internalization processes. FASEB J; 29(6):2235-46.

Tora AS, Rovira X, Dione I, Bertrand HO, Brabet I, De Koninck Y, Doyon N, Pin JP, Acher F, Goudet C (2015). Allosteric modulation of metabotropic glutamate receptors by chloride ions. FASEB J; 29(10):4174-88.

2014

Gaillard S, Lo Re L, Mantilleri A, Hepp R, Urien L, Malapert P, Alonso S, Deage M, Kambrun C, Landry M, A Low S, Alloui A, Lambolez B, Scherrer G, Le Feuvre Y, Bourinet E and Moqrich A (2014). GINIP, a new Gi interacting protein, functions as a key modulator of peripheral GABAB receptor-mediated analgesia. Neuron; 84(1): 123-36.

Duhr F, Déléris P, Raynaud F, Séveno M, Morisset-Lopez S, Mannoury la Cour C, Millan MJ, Bockaert J, Marin P, Chaumont-Dubel S (2014) Cdk5 induces constitutive activation of 5-HT6 receptors to promote neurite growth. Nat Chem Biol

Bjordal M, Arquier N, Kniazeff J, Pin JP, Léopold P (2014). Sensing of amino acids in a dopaminergic circuitry promotes rejection of an incomplete diet in Drosophila. Cell 30 ;156(3):510-21.

2013

Cochet M, Donneger R, Cassier E, Gaven F, Lichtenthaler SF, Marin P, Bockaert J, Dumuis A, Claeysen S (2013). 5-HT4 receptors constitutively promote the non-amyloidogenic pathway of APP cleavage and interact with ADAM10. ACS Chem Neurosci 16 ;4(1):130-40.

Doumazane, Scholler P, Fabre L, Zwier JM, Trinquet E, Pin JP, Rondard P (2013). Illuminating the activation mechanisms and allosteric properties of metabotropic glutamate receptors. PNAS 110(15):E1416-25.

Gaven F, Pellissier LP, Queffeulou E, Cochet M, Bockaert J, Dumuis A, Claeysen S (2013). Pharmacological profile of engineered 5-HT₄ receptors and identification of 5-HT₄ receptor-biased ligands. Brain Res. 20 ;1511:65-72.

Xu C, Peter M, Bouquier N, Ollendorff V, Villamil I, Liu J, Fagni L, Perroy J (2013). REV, A BRET-Based Sensor of ERK Activity. Front Endocrinol 30 ;4:95.

2012

Moutin E, Raynaud F, Roger J, Pellegrino E, Homburger V, Bertaso F, Ollendorf V, Bockaert J, Fagni L and Perroy J (2012). Dynamic remodeling of scaffold interactions in dendritic spines controls synaptic excitability. JCB.

Comps-Agrar L, Kniazeff J, Brock C, Trinquet E, Pin JP (2012). Stability of GABAB receptor oligomers revealed by dual TR-FRET and drug-induced cell surface targeting. FASEB J.

Compan V, Ulmann L, Stelmashenko O, Chemin J, Chaumont S, Rassendren F (2012). P2X2 and P2X5 subunits define a new heteromeric receptor with P2X7-like properties. J Neurosci. 32(12):4284-96.

Rahmeh R, Damian M, Cottet M, Orcel H, Mendre C, Durroux T, Sharma KS, Durand G, Pucci B, Trinquet E, Zwier JM, Deupi X, Bron P, Banères JL, Mouillac B, Granier S (2012). Structural insights into biased G protein-coupled receptor signaling revealed by fluorescence spectroscopy. PNAS. 109(17):6733-8.

Fazio F, Lionetto L, Molinaro G, Bertrand HO, Acher F, Ngomba RT, Notartomaso S, Curini M, Rosati O, Scarselli P, Di Marco R, Battaglia G, Bruno V, Simmaco M, Pin JP, Nicoletti F and Goudet C (2012). Cinnabarinic Acid, an Endogenous Metabolite of the Kynurenine Pathway, Activates Type-4 Metabotropic Glutamate Receptors. Mol Pharmacol. 81(5):643-56.

Goudet C, Vilar B, Courtiol T, Deltheil T, Bessiron T, Brabet I, Oueslati N, Rigault D, Bertrand HO, McLean H, Daniel H, Amalric M, Acher F, Pin JP (2012). A novel selective metabotropic glutamate receptor 4 agonist reveals new possibilities for developing subtype selective ligands with therapeutic potential. FASEB J.

2011

Pellissier LP, Barthet G, Gaven F, Cassier E, Trinquet E, Pin JP, Marin P, Dumuis A, Bockaert J, Banères JL, Claeysen S (2011). G protein activation by serotonin type 4 receptor dimers : evidence that turning on two protomers is more efficient. JBC. 286(12):9985-97.

Huang S, Cao J, Jiang M, Labesse G, Liu J, Pin JP, Rondard P (2011) Interdomain movements in metabotropic glutamate receptor activation. PNAS. 108(37):15480-5.

Comps-Agrar L, Kniazeff J, Maurel D, Gassmann M, Gregor N, Prézeau L, Bettler B, Durroux T, Trinquet E, Pin JP (2011). The oligomeric state sets GABAB receptor functioning. EMBO J. 30(12):2336-49.

Doumazane, E., Scholler, P., Zwier, J. M., Trinquet, E., Rondard, P., Pin, J.-P. (2011). A new approach to analyze cell surface protein complexes reveals specific heterodimeric metabotropic glutamate receptors. FASEB J. 25, 66–77.

Acher FC, Selvam C, Pin JP, Goudet C, Bertrand HO (2011). A critical pocket close to the glutamate binding site of mGlu receptors opens new possibilities for agonist design. Neuropharm. 60(1):102-7

2010

Ayoub MA, Trinquet E, Pfleger KD, Pin JP (2010). Differential association modes of the thrombin receptor PAR1 with Galphai1, Galpha12, and beta-arrestin 1. FASEB J. 24(9):3522-35.

Martín R, Durroux T, Ciruela F, Torres M, Pin JP, Sánchez-Prieto J (2010). The metabotropic glutamate receptor mGlu7 activates phospholipase C, translocates munc-13-1 protein, and potentiates glutamate release at cerebrocortical nerve terminals. JBC. 285(23):17907-17.

Albizu L, Cottet M, Kralikova M, Stoev S, Seyer R, Brabet I, Roux T, Bazin H, Bourrier E, Lamarque L, Breton C, Rives ML, Newman A, Javitch J, Trinquet E, Manning M, Pin JP, Mouillac B, Durroux T (2010). Time-resolved FRET between GPCR ligands reveals oligomers in native tissues. Nat Chem Biol. Aug ;6(8):587-94.

2009

Beurrier C, Lopez S, Révy D, Selvam C, Goudt C, Lhérondel M, Gubellini P, Kerkerian-LeGoll L, Acher F, Pin JP, and Amalric M (2009). Electrophysiological and behavioral evidence that modulation of metabotropic glutamate receptor 4 with a new agonist reverses experimental parknsonism. The FASEB Journal. 23(10):3619-28.

Monnier C, Dodé C, Fabre L, Teixeira L, Labesse G, Pin JP, Hardelin JP, and Rondard P (2009). PROKR2 missense mutations associated with Kallmann syndrome impair receptor signalling activity. Hum Mol Genet. 18(1):75-81.

Rives ML, Vol C, Fukazawa Y, Tinel N, Trinquet E, Ayoub MA, Shigemoto R, Pin JP, Prézeau L. (2009). Cross regulation between mGlu1a and GABAB receptors does not involved direct physical interaction. EMBO J. 28(15):2195-208.

Barthet G, Carrat G, Cassier E, Barker B, Gaven F, Pillot M, Framery B, Pellissier LP, Augier J, Kang DS, Claeysen S, Reiter E, Banères JL, Benovic JL, Marin P, Bockaert J, Dumuis A (2009). Beta-arrestin1 phosphorylation by GRK5 regulates G protein-independent 5-HT4 receptor signalling. EMBO J. 28(18):2706-18.

Pellissier LP, Sallander J, Campillo M, Gaven F, Queffeulou E, Pillot M, Dumuis A, Claeysen S, Bockaert J, Pardo L (2009). Conformational toggle switches implicated in basal constitutive and agonist-induced activated states of 5-hydroxytryptamine-4 receptors. Mol Pharmacol. 75(4):982-90.

2008

Chen Y, Goudet C, Pin JP, and Conn J (2008). N-(4-chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl)- 2-hydroxybenzamide (CPPHA) acts through a novel site as a positive allosteric modlator of group 1 metabotropic glutamate receptors. Molecular Pharmacol. 73(3):909-18.

Goudet Cyril, Chapuy Eric, Alloui Adelkrim, Acher Francine, Pin Jean-Philippe, Eschalier Alain (2008). Group III metabotropic glutamate receptors inhibit hyperalgesia in animal models of inflammation and neuropathic pain. Pain. 137(1):112-24.

Maurel Damien, Comps-Agrar Laetitia, Brock Carsten, Rives Marie-Laure, Bourrier Emmaneul, Ayoub Mohammed, Bazin Hervé, Tinel Nobert, Durroux Thierry, Prézeau Laurent, Trinquet Eric, Pin Jean-Philippe (2008). Cell-surface protein-protein interaction analysis with the time-resolved FRET and Snap-tag technologies : application to GPCR oligomerization. Nat. Methods. 5(6):561-7.

Rondard P, Huang S, Monnier C, Tu H, Blanchard B, Oueslati N, Malhaire F, Li Y, Trinquet E, Labesse G, Pin JP, Liu JF (2008). Functioning of the dimeric GABA(B) receptor extracellular domain revealed by glycan wedge scanning. EMBO J. 27(9):1321-32.

2007

Albizu L, Teppaz G, Seyer R, Bazin H, Ansanay H, Manning M, Mouillac B, Durroux T (2007). Toward efficient drug screening by homogeneous assays based on the development of new fluorescent vasopressin and oxytocin receptor ligands. J Med Chem. 50(20):4976-85.

Ayoub MA, Maurel D, Binet V, Fink M, Prézeau L, Ansanay H, Pin J-P (2007). Real-time analysis of agonist-induced activation of Protease-activated receptor 1 / Gαi1 protein complex measured by BRET in living cells. Mol Pharmacol. 71(5):1329-40.

Binet V, Duthey B, Lecaillon J, Vol C, Quoyer J, Labesse G, Pin J-P, Prézeau L (2007). Common Structural requirements for Heptahelical Domain Function in Class A and Class C GPCRs. J Biol Chem. 282(16):12154-63.

Chanrion B, Mannoury la Cour C, Bertaso, Lerner-Natoli M, Freissmuth M, Millan MJ, Bockaert J and Marin P (2007). A physical interaction between the serotonin transporter and neuronal NO synthase underlies reciprocal modulation of their activity. Proc Natl Acad Sci (USA). 104(19):8119-24.

Jean A, Conductier G, Manrique C, Bouras C, Berta P, Hen R, Charnay Y, Bockaert J, Compan V (2007). Anorexia induced by activation of serotonin 5-HT4 receptors is mediated by increases in CART in the nucleus accumbens. Proc Natl Acad Sci (USA). 104(41):16335-40.

Chen Y, Nong Y, Goudet C, Hemstapat K, de Paulis T, Pin J-P, Conn PJ (2007). Activity of novel positive allosteric modulators of metabotropic glutamate receptor 5 requires binding to the same site as allosteric antagonists.

Demange Luc, Boeglin Damien, Moulin Aline, Mousseaux Delphine, Ryan Joanne, Bergé Gilbert, Gagne Didier, Heitz Annie, Perrissoud Daniel, Locatelli Vittorio, Torsello Antonio, Galleyrand Jean-Claude, Fehrentz Jean-Alain, Martinez Jean (2007). Synthesis and Pharmacological in vitro and in vivo : Evaluations of Novel Triazole Derivatives as Ligands of the Ghrelin Receptor 1. J. Med. Chem. 50 :1939-57. Institut Max Mousseron, équipe JA Fehrentz

Juvin Véronique, Penna Aubin, Chemin Jean, Lin Yea-Lih, Rassendren François-André (2007). Pharmacological characterization and molecular determinants of the activation o TRPV2 channels orthologs by 2-aminoethoxydiphenyl borate. Molecular Pharmacol. 72. 1258-1268.

Selvam Chelliah, Goudet C, Oueslati N, Pin J-P, Acher F (2007). L-(+)-2-amino-4-thiophosphonobutyric acid (L-thio-AP4), a new potent agonist of group III metabotropic glutamate receptor : increased distal acidity affords enhanced potency. J. Med. Chem. 50 :4656-64.

2022

Kampen S, Rodríguez D, Jørgensen M, Kruszyk-Kujawa M, Huang X, Collins M, Boyle N, Maurel D, Rudling A, Lebon G, and Carlsson J (2022). Structure-Based Discovery of Negative Allosteric Modulators of the 2 Metabotropic Glutamate Receptor 5. ACS Chem Biol. DOI: 10.1021/acschembio.2c00234

Liu J, Hengmin Tang, Xu C, Zhou S, Zhu X, Li Y, Prézeau L, Xu T, Pin JP, Rondard P, Ji W, Liu J (2022). Biased signaling due to oligomerization of the G protein-coupled platelet-activating factor receptor. Nat Commun. 2022; 13: 6365. doi: 10.1038/s41467-022-34056-4

Gazdarica M, Noda J, Durydivka O, Novosadova V, Mackie K, Pin JP, Prezeau L, Blahos J. (2022). SGIP1 modulates kinetics and interactions of the cannabinoid receptor 1 and G protein‐coupled receptor kinase 3 signalosome. J Neurochem. 2022 Mar; 160(6): 625–642. doi: 10.1111/jnc.15569

A. Mills, N. Aissaoui, D. Maurel, J. Elezgaray, F. Morvan, J. J. Vasseur, E. Margeat, R. B. Quast, J. Lai Kee-Him, N. Saint, C. Benistant, A. Nord, F. Pedaci, G. Bellot (2022). A modular spring-loaded actuator for mechanical activation of membrane proteins. Nature Com. DOI: 10.1038/s41467-022-30745-2

Meng J, Xu C, Lafon PA, Roux S, Mathieu M, Zhou R, Scholler P, Blanc E, Becker J, Le Merrer J, González-Maeso J, Chames P, Liu J, Pin Jp, Rondard P (2022). Nanobody-based sensors reveal a high proportion of mGlu heterodimers in the brain. Nat Chem Biol. DOI: 10.1038/s41589-022-01050-2

Bous  J, Fouillen  A, Orcel  H , Trapani  S , Cong  X, Fontanel  S , Saint-Paul  J, Lai-Kee-Him  J, Urbach  S, Sibille  N, Sounier  R, Granier  S, Mouillac B, Bron  P (2022). Structure of the vasopressin hormone-V2 receptor-β-arrestin1 ternary complex. Sci Adv. DOI: 10.1126/sciadv.abo7761

2021

Cong X, Maurel D, Déméné H, Vasiliauskaité-Brooks I, Hagelberger J, PeyssonF, Saint-Paul J, Golebiowski J, Granier S, Sounier R (2021). Molecular insights into the biased signaling mechanism of the μ-opioid receptor. Molecular Cell. DOI: 10.1016/j.molcel.2021.07.033

Lemel L, Niescierowicz1 K, García-Fernandez MD, Darré L, Durroux T, Busnelli, Pezet M, Rébeillé F , Jouhet J, Mouillac B, Domene C, Chini B, Cherezov V and Moreau CJ (2021). The ligand-bound state of a G protein-coupled receptor stabilizes the interaction of functional cholesterol molecules. doi: 10.1016/j.jlr.2021.100059

Grison CM, Lambey P, Jeannot S, Del Nero E, Fontanel S, Peysson F, Heuninck J, Sounier R, Durroux T, Leyrat C, Granier S and Bechara C (2021). Molecular insights into mechanisms of GPCR hijacking by Staphylococcus aureus. PNAS. DOI: 10.1073/pnas.2108856118

Healey RD, Saied EM, Cong X, Karsai G, Gabellier L, Saint Paul J, Del Nero E, Jeannot S, Drapeau M, Fontanel S, Maurel D, Basu S, Leyrat C, Golebiowski J, Bossis G, Bechara C, Hornemann T, Arenz C, Granier S (2021). Discovery and mechanism of action of small molecule inhibitors of ceramidases. Angewandte Chemie. https://doi.org/10.1002/anie.202109967

Haubrich J, Font J, Quast RB, Goupil-Lamy A, Scholler P, Nevoltris D, Acher F, Chames P, Rondard P, Prézeau L, and Pin JP (2021). A nanobody activating metabotropic glutamate receptor 4 discriminates between homo- and heterodimers. PNAS. doi:10.1073/pnas.2105848118

Zindel  D , Mensat P , Vol  C , Homayed  Z , Charrier-Savournin  F , Trinquet  E , Banères  JL, Pin  JP , Pannequin  J , Roux  T , Dupuis  E, Prézeau  L. (2021). G protein-coupled receptors can control the Hippo/YAP pathway through Gq signaling. FASEB J. doi: 10.1096/fj.202002159R.

Nasrallah C, Cannone C, Briot J, Rottier K, Berizzi AE, Huang CY, Quast RB, Hoh F, Banères JL, Malhaire F, Berto L, Dumazer A, Font-Ingles J, Gómez-Santacana X, Catena J, Kniazeff J, Goudet C, Llebaria A, Pin JP, Vinothkumar KR, and Guillaume Lebon. Agonists and allosteric modulators promote signaling from different metabotropic glutamate receptor 5 conformations (2021). Cell Rep. doi: 10.1016/j.celrep.2021.109648

Lemel L, Niescierowicz K, García-Fernandez MD, Darre L , Durroux T, Busnelli M, Pezet M, Rebeille F , Jouhet J, Mouillac B, Domene C, Chini B, Cherezov V, and Moreau CJ (2021). The ligand-bound state of a G protein-coupled receptor stabilizes the interaction of functional cholesterol molecules. J. Lipid Res. https://doi.org/10.1016/j.jlr.2021.100059

Ollivier M, Beudez J, Linck N, Grutter T, Compan V and Rassendren F (2021). P2X-GCaMPs as Versatile Tools for Imaging Extracellular ATP Signaling. eNEURO. https://doi.org/10.1523/ENEURO.0185-20.2020

2020

Gentzsch C, Seier K, Drakopoulos A, Jobin ML, Lanoiselée Y, Koszegi Z, Maurel D, Sounier R, Hübner H, Gmeiner P, Granier S, Calebiro D, Decker M (2019). Selective and Wash‐Resistant Fluorescent Dihydrocodeinone‐Derivatives Allow Single‐Molecule Imaging of mu‐Opioid Receptor Dimerisation. Angewandte Chemie. https://doi.org/10.1002/anie.201912683.

Liu H, Yi  P, Zhao W, Wu Y, Acher F, Pin  JP, Liu J, Rondard P (2020). Illuminating the allosteric modulation of the calcium-sensing receptor. PNAS. DOI: 10.1073/pnas.1922231117

Fumagalli A, Heuninck J, Pizzoccaro A, Moutin E, Koenen J, Séveno M, Durroux T, Marie-Pierre Junier, Géraldine Schlecht-Louf, Francoise Bachelerie, Dagmar Schütz, Ralf Stumm, Martine J. Smit, Nathalie C. Guérineau, Séverine Chaumont-Dubel & Philippe Marin (2020). The atypical chemokine receptor 3 interacts withcConnexin 43 inhibiting astrocytic gap junctional intercellular communication. Nature Comm. DOI : https://doi.org/10.1038/s41467-020-18634-y

Sebastianutto I, Goyet E, Andreoli L, Font-Ingles J, Moreno-Delgado D, Bouquier N, Jahannault-Talignani C, Moutin E, Di Menna L, Maslava N, Pin JP, Fagni L, Nicoletti F, Ango F, Cenci MA, and Perroy J (2020). D1-mGlu5 heteromers mediate noncanonical dopamine signaling in Parkinson’s disease. The Journal of Clinical Investigation. https://doi.org/10.1172/JCI126361

Shaye H, Ishchenko A, Homing Lam J, Won Han G , Xue L, Rondard P, Pin JP, Katritch V, Gati C, and Cherezov.  Structural basis of the activation of a metabotropic GABA receptor (2020). Nature. DOI : 10.1038/s41586-020-2408-4

Moutin E, Hemonnot AL, Seube V, Linck N, Rassendren F, Perroy J and Compan V. Procedures for Culturing and Genetically Manipulating Murine Hippocampal Postnatal Neurons (2020). https://doi.org/10.3389/fnsyn.2020.00019

Cubizolle A, Cia D, Moine E, Jacquemot N, Guillou L, Rosell M, Angebault-Prouteau C, Lenaers G, Meunier I, Vercauteren J, Durand T, Crauste C, Brabet P. Isopropyl-phloroglucinol-DHA protects outer retinal cells against lethal dose of all-trans-retinal (2020). J Cell Mol Med. DOI: 10.1111/jcmm.15135

2019

Zindel D, Vol C, Lecha O, Bequignon I, Bilgic M, Vereecke M, Charrier-Savournin F, Romier M, Trinquet E, Pin JP, Pannequin J, Roux T, Dupuis E, Prézeau L (2019). HTRF® Total and Phospho-YAP (Ser127) Cellular Assays. Methods Mol Biol. 1893:153-166.

Heuninck J, Hounsou C, Dupuis E, Trinquet E, Mouillac B, Pin JP, Bonnet D, Durroux T. Time-Resolved FRET-Based Assays to Characterize G Protein-Coupled Receptor Hetero-oligomer Pharmacology (2019). Methods Mol Biol. 1947:151-168.

Hajj M, De Vita T, Vol C, Renassia C, Bologna JC, Brabet I, Cazade M, Pastore M, Blahos J, Labesse G, Pin JP, Prézeau L (2019). Nonclassical Ligand-Independent Regulation of Go Protein by an Orphan Class C G-Protein–Coupled Receptor. Mol Pharmacol. Aug;96(2):233-246.

2018

Belhocine A, Veglianese P, Hounsou C, Dupuis E, Acher F, Durroux T, Goudet C, Pin JP. Profiling of orthosteric and allosteric group-III metabotropic glutamate receptor ligands on various G protein-coupled receptors with Tag-lite^® assays. Neuropharmacology. 2018;140: 233-245.

Tora AS, Rovira X, Cao AM, Cabayé A, Olofsson L, Malhaire F, Scholler P, Baik H, Van Eeckhaut A, Smolders I, Rondard P, Margeat E, Acher F, Pin JP, Goudet C. Chloride ions stabilize the glutamate-induced active state of the metabotropic glutamate receptor 3. Neuropharmacology. 2018;140: 275-286.

Nasrallah C, Rottier K, Marcellin R, Compan V, Font J, Llebaria A, Pin JP, Banères JL, Lebon G (2018). Direct coupling of detergent purified human mGlu5 receptor to the heterotrimeric G proteins Gq and Gs. Sci Rep. 2018 Mar 13;8(1):4407.

Selvam C, Lemasson IA, Brabet I, Oueslati N, Karaman B, Cabaye A, Tora AS, Commare B, Courtiol T, Cesarini S, McCort-Tranchepain I, Rigault D, Mony L, Bessiron T, McLean H, Leroux FR, Colobert F, Daniel H, Goupil-Lamy A, Bertrand HO, Goudet C, Pin JP, Acher FC (2018). Increased Potency and Selectivity for Group III Metabotropic Glutamate Receptor Agonists Binding at Dual sites. J Med Chem.  Mar 8;61(5):1969-1989.

Stewart GD, Comps-Agrar L, Nørskov-Lauritsen LB, Pin JP, Kniazeff J. Allosteric interactions between GABAB1 subunits control orthosteric binding sites occupancy within GABAB oligomers 2018). Neuropharmacology. Jan 2, S0028-3908(17)30640-8.

2017

Moreno Delgado D, Møller TC, Ster J, Giraldo J, Maurel D, Rovira X, Scholler P, Zwier JM, Perroy J, Durroux T, Trinquet E, Prezeau L, Rondard P, Pin JP (2017). Pharmacological evidence for a metabotropic glutamate receptor heterodimer in neuronal cells. Elife. 29;6.

Lecat-Guillet N, Monnier C, Rovira X, Kniazeff J, Lamarque L, Zwier JM, Trinquet E, Pin JP, Rondard P (2017). FRET-Based Sensors Unravel Activation and Allosteric Modulation of the GABAB Receptor. Cell Chem Biol. 16;24(3):360-370.

Scholler P, Moreno-Delgado D, Lecat-Guillet N, Doumazane E, Monnier C, Charrier-Savournin F, Fabre L, Chouvet C, Soldevila S, Lamarque L, Donsimoni G, Roux T, Zwier JM, Trinquet E, Rondard P, Pin JP (2017). HTS-compatible FRET-based conformational sensors clarify membrane receptor activation. Nat Chem Biol. 13(4):372-380.

Perkovska S, Méjean C, Ayoub MA, Li J, Hemery F, Corbani M, Laguette N, Ventura MA, Orcel H, Durroux T, Mouillac B, Mendre C (2017). V1b vasopressin receptor trafficking and signaling : role of arrestins, G proteins and Src kinase. Traffic. 16.

Duquenne C, Gimenez S, Guigues A, Viala B, Boulouis C, Mettling C, Maurel D, Campos N, Doumazane E, Comps-Agrar L, Tazi J, Prézeau L, Corbeau P, François V (2017). Reversing HIV latency via sphingosine-1-phosphate receptor 1 signaling. AIDS. Sep 18.

2016

Hájková A, Techlovská Š, Dvořáková M, Chambers JN, Kumpošt J, Hubálková P, Prezeau L, Blahos J (2016). SGIP1 alters internalization and modulates signaling of activated cannabinoid receptor 1 in a biased manner. Neuropharmacology. 107:201-214.

Broad J, Maurel D, Kung VWS, Hicks GA, Schemann M, Barnes MR, Kenakin TP, Granier S, Sanger GJ (2016). Human native kappa opioid receptor functions not predicted by recombinant receptors: Implications for drug design. Scientific Reports. 6:30797.

Goyet E, Bouquier N, Ollendorff V, Perroy J (2016). Fast and high resolution single-cell BRET imaging. Scientific Reports 6:28231.

Zussy C, Gómez-Santacana X, Rovira X, De Bundel D, Ferrazzo S, Bosch D, Asede D, Malhaire F, Acher F, Giraldo J, Valjent E, Ehrlich I, Ferraguti F, Pin JP, Llebaria A and Goudet C (2016). Dynamic modulation of inflammatory pain-related affective and sensory symptoms by optical control of amygdala metabotropic glutamate receptor 4. Molecular Psychiatry. 00, 1–12.

2015

Levoye A, Zwier JM, Jaracz-Ros A, Klipfel L, Cottet M, Maurel D, Bdioui S, Balabanian K, Prézeau L, Trinquet E, Durroux T, Bachelerie F (2015). A Broad G Protein-Coupled Receptor Internalization Assay that Combines SNAP-Tag Labeling, Diffusion-Enhanced Resonance Energy Transfer, and a Highly Emissive Terbium Cryptate. Front Endocrinol (Lausanne). 9;6:167.

Zampieri A, Champagne J, Auzemery B, Fuentes I, Maurel B, Bienvenu F (2015). Hyper sensitive protein detection by Tandem-HTRF reveals Cyclin D1 dynamics in adult mouse. Scientific Reports; 5: 15739.

Rovira X, Malhaire F, Scholler P, Rodrigo J, Gonzalez-Bulnes P, Llebaria A, Pin JP, Giraldo J, Goudet C (2015). Overlapping binding sites drive allosteric agonism and positive cooperativity in type 4 metabotropic glutamate receptors. FASEB J; 29(1):116-30.

Hounsou C, Margathe J, Oueslati N, Belhocine A, Dupuis E, Thomas C, Mann A, Ilien B, Rognan D, Trinquet E, Hibert M, Pin JP, Bonnet D, Durroux T (2015). Time-resolved FRET binding assay to investigate hetero-oligomer binding properties: proof of concept with dopamine D1/D3 heterodimer. ACS Chem Biol; 20;10(2):466-74.

Oueslati N, Hounsou C, Belhocine A, Rodriguez T, Dupuis E, Zwier JM, Trinquet E, Pin JP, Durroux T (2015). Time-resolved FRET strategy to screen GPCR ligand library. Methods Mol Biol.; 1272:23-36.

Faklaris O, Cottet M, Falco A, Villier B, Laget M, Zwier JM, Trinquet E, Mouillac B, Pin JP, Durroux T. Multicolor time-resolved Förster resonance energy transfer microscopy reveals the impact of GPCR oligomerization on internalization processes. FASEB J; 29(6):2235-46.

Tora AS, Rovira X, Dione I, Bertrand HO, Brabet I, De Koninck Y, Doyon N, Pin JP, Acher F, Goudet C (2015). Allosteric modulation of metabotropic glutamate receptors by chloride ions. FASEB J; 29(10):4174-88.

2014

Gaillard S, Lo Re L, Mantilleri A, Hepp R, Urien L, Malapert P, Alonso S, Deage M, Kambrun C, Landry M, A Low S, Alloui A, Lambolez B, Scherrer G, Le Feuvre Y, Bourinet E and Moqrich A (2014). GINIP, a new Gi interacting protein, functions as a key modulator of peripheral GABAB receptor-mediated analgesia. Neuron; 84(1): 123-36.

Duhr F, Déléris P, Raynaud F, Séveno M, Morisset-Lopez S, Mannoury la Cour C, Millan MJ, Bockaert J, Marin P, Chaumont-Dubel S (2014) Cdk5 induces constitutive activation of 5-HT6 receptors to promote neurite growth. Nat Chem Biol

Bjordal M, Arquier N, Kniazeff J, Pin JP, Léopold P (2014). Sensing of amino acids in a dopaminergic circuitry promotes rejection of an incomplete diet in Drosophila. Cell 30 ;156(3):510-21.

2013

Cochet M, Donneger R, Cassier E, Gaven F, Lichtenthaler SF, Marin P, Bockaert J, Dumuis A, Claeysen S (2013). 5-HT4 receptors constitutively promote the non-amyloidogenic pathway of APP cleavage and interact with ADAM10. ACS Chem Neurosci 16 ;4(1):130-40.

Doumazane, Scholler P, Fabre L, Zwier JM, Trinquet E, Pin JP, Rondard P (2013). Illuminating the activation mechanisms and allosteric properties of metabotropic glutamate receptors. PNAS 110(15):E1416-25.

Gaven F, Pellissier LP, Queffeulou E, Cochet M, Bockaert J, Dumuis A, Claeysen S (2013). Pharmacological profile of engineered 5-HT₄ receptors and identification of 5-HT₄ receptor-biased ligands. Brain Res. 20 ;1511:65-72.

Xu C, Peter M, Bouquier N, Ollendorff V, Villamil I, Liu J, Fagni L, Perroy J (2013). REV, A BRET-Based Sensor of ERK Activity. Front Endocrinol 30 ;4:95.

2012

Moutin E, Raynaud F, Roger J, Pellegrino E, Homburger V, Bertaso F, Ollendorf V, Bockaert J, Fagni L and Perroy J (2012). Dynamic remodeling of scaffold interactions in dendritic spines controls synaptic excitability. JCB.

Comps-Agrar L, Kniazeff J, Brock C, Trinquet E, Pin JP (2012). Stability of GABAB receptor oligomers revealed by dual TR-FRET and drug-induced cell surface targeting. FASEB J.

Compan V, Ulmann L, Stelmashenko O, Chemin J, Chaumont S, Rassendren F (2012). P2X2 and P2X5 subunits define a new heteromeric receptor with P2X7-like properties. J Neurosci. 32(12):4284-96.

Rahmeh R, Damian M, Cottet M, Orcel H, Mendre C, Durroux T, Sharma KS, Durand G, Pucci B, Trinquet E, Zwier JM, Deupi X, Bron P, Banères JL, Mouillac B, Granier S (2012). Structural insights into biased G protein-coupled receptor signaling revealed by fluorescence spectroscopy. PNAS. 109(17):6733-8.

Fazio F, Lionetto L, Molinaro G, Bertrand HO, Acher F, Ngomba RT, Notartomaso S, Curini M, Rosati O, Scarselli P, Di Marco R, Battaglia G, Bruno V, Simmaco M, Pin JP, Nicoletti F and Goudet C (2012). Cinnabarinic Acid, an Endogenous Metabolite of the Kynurenine Pathway, Activates Type-4 Metabotropic Glutamate Receptors. Mol Pharmacol. 81(5):643-56.

Goudet C, Vilar B, Courtiol T, Deltheil T, Bessiron T, Brabet I, Oueslati N, Rigault D, Bertrand HO, McLean H, Daniel H, Amalric M, Acher F, Pin JP (2012). A novel selective metabotropic glutamate receptor 4 agonist reveals new possibilities for developing subtype selective ligands with therapeutic potential. FASEB J.

2011

Pellissier LP, Barthet G, Gaven F, Cassier E, Trinquet E, Pin JP, Marin P, Dumuis A, Bockaert J, Banères JL, Claeysen S (2011). G protein activation by serotonin type 4 receptor dimers : evidence that turning on two protomers is more efficient. JBC. 286(12):9985-97.

Huang S, Cao J, Jiang M, Labesse G, Liu J, Pin JP, Rondard P (2011) Interdomain movements in metabotropic glutamate receptor activation. PNAS. 108(37):15480-5.

Comps-Agrar L, Kniazeff J, Maurel D, Gassmann M, Gregor N, Prézeau L, Bettler B, Durroux T, Trinquet E, Pin JP (2011). The oligomeric state sets GABAB receptor functioning. EMBO J. 30(12):2336-49.

Doumazane, E., Scholler, P., Zwier, J. M., Trinquet, E., Rondard, P., Pin, J.-P. (2011). A new approach to analyze cell surface protein complexes reveals specific heterodimeric metabotropic glutamate receptors. FASEB J. 25, 66–77.

Acher FC, Selvam C, Pin JP, Goudet C, Bertrand HO (2011). A critical pocket close to the glutamate binding site of mGlu receptors opens new possibilities for agonist design. Neuropharm. 60(1):102-7

2010

Ayoub MA, Trinquet E, Pfleger KD, Pin JP (2010). Differential association modes of the thrombin receptor PAR1 with Galphai1, Galpha12, and beta-arrestin 1. FASEB J. 24(9):3522-35.

Martín R, Durroux T, Ciruela F, Torres M, Pin JP, Sánchez-Prieto J (2010). The metabotropic glutamate receptor mGlu7 activates phospholipase C, translocates munc-13-1 protein, and potentiates glutamate release at cerebrocortical nerve terminals. JBC. 285(23):17907-17.

Albizu L, Cottet M, Kralikova M, Stoev S, Seyer R, Brabet I, Roux T, Bazin H, Bourrier E, Lamarque L, Breton C, Rives ML, Newman A, Javitch J, Trinquet E, Manning M, Pin JP, Mouillac B, Durroux T (2010). Time-resolved FRET between GPCR ligands reveals oligomers in native tissues. Nat Chem Biol. Aug ;6(8):587-94.

2009

Beurrier C, Lopez S, Révy D, Selvam C, Goudt C, Lhérondel M, Gubellini P, Kerkerian-LeGoll L, Acher F, Pin JP, and Amalric M (2009). Electrophysiological and behavioral evidence that modulation of metabotropic glutamate receptor 4 with a new agonist reverses experimental parknsonism. The FASEB Journal. 23(10):3619-28.

Monnier C, Dodé C, Fabre L, Teixeira L, Labesse G, Pin JP, Hardelin JP, and Rondard P (2009). PROKR2 missense mutations associated with Kallmann syndrome impair receptor signalling activity. Hum Mol Genet. 18(1):75-81.

Rives ML, Vol C, Fukazawa Y, Tinel N, Trinquet E, Ayoub MA, Shigemoto R, Pin JP, Prézeau L. (2009). Cross regulation between mGlu1a and GABAB receptors does not involved direct physical interaction. EMBO J. 28(15):2195-208.

Barthet G, Carrat G, Cassier E, Barker B, Gaven F, Pillot M, Framery B, Pellissier LP, Augier J, Kang DS, Claeysen S, Reiter E, Banères JL, Benovic JL, Marin P, Bockaert J, Dumuis A (2009). Beta-arrestin1 phosphorylation by GRK5 regulates G protein-independent 5-HT4 receptor signalling. EMBO J. 28(18):2706-18.

Pellissier LP, Sallander J, Campillo M, Gaven F, Queffeulou E, Pillot M, Dumuis A, Claeysen S, Bockaert J, Pardo L (2009). Conformational toggle switches implicated in basal constitutive and agonist-induced activated states of 5-hydroxytryptamine-4 receptors. Mol Pharmacol. 75(4):982-90.

2008

Chen Y, Goudet C, Pin JP, and Conn J (2008). N-(4-chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl)- 2-hydroxybenzamide (CPPHA) acts through a novel site as a positive allosteric modlator of group 1 metabotropic glutamate receptors. Molecular Pharmacol. 73(3):909-18.

Goudet Cyril, Chapuy Eric, Alloui Adelkrim, Acher Francine, Pin Jean-Philippe, Eschalier Alain (2008). Group III metabotropic glutamate receptors inhibit hyperalgesia in animal models of inflammation and neuropathic pain. Pain. 137(1):112-24.

Maurel Damien, Comps-Agrar Laetitia, Brock Carsten, Rives Marie-Laure, Bourrier Emmaneul, Ayoub Mohammed, Bazin Hervé, Tinel Nobert, Durroux Thierry, Prézeau Laurent, Trinquet Eric, Pin Jean-Philippe (2008). Cell-surface protein-protein interaction analysis with the time-resolved FRET and Snap-tag technologies : application to GPCR oligomerization. Nat. Methods. 5(6):561-7.

Rondard P, Huang S, Monnier C, Tu H, Blanchard B, Oueslati N, Malhaire F, Li Y, Trinquet E, Labesse G, Pin JP, Liu JF (2008). Functioning of the dimeric GABA(B) receptor extracellular domain revealed by glycan wedge scanning. EMBO J. 27(9):1321-32.

2007

Albizu L, Teppaz G, Seyer R, Bazin H, Ansanay H, Manning M, Mouillac B, Durroux T (2007). Toward efficient drug screening by homogeneous assays based on the development of new fluorescent vasopressin and oxytocin receptor ligands. J Med Chem. 50(20):4976-85.

Ayoub MA, Maurel D, Binet V, Fink M, Prézeau L, Ansanay H, Pin J-P (2007). Real-time analysis of agonist-induced activation of Protease-activated receptor 1 / Gαi1 protein complex measured by BRET in living cells. Mol Pharmacol. 71(5):1329-40.

Binet V, Duthey B, Lecaillon J, Vol C, Quoyer J, Labesse G, Pin J-P, Prézeau L (2007). Common Structural requirements for Heptahelical Domain Function in Class A and Class C GPCRs. J Biol Chem. 282(16):12154-63.

Chanrion B, Mannoury la Cour C, Bertaso, Lerner-Natoli M, Freissmuth M, Millan MJ, Bockaert J and Marin P (2007). A physical interaction between the serotonin transporter and neuronal NO synthase underlies reciprocal modulation of their activity. Proc Natl Acad Sci (USA). 104(19):8119-24.

Jean A, Conductier G, Manrique C, Bouras C, Berta P, Hen R, Charnay Y, Bockaert J, Compan V (2007). Anorexia induced by activation of serotonin 5-HT4 receptors is mediated by increases in CART in the nucleus accumbens. Proc Natl Acad Sci (USA). 104(41):16335-40.

Chen Y, Nong Y, Goudet C, Hemstapat K, de Paulis T, Pin J-P, Conn PJ (2007). Activity of novel positive allosteric modulators of metabotropic glutamate receptor 5 requires binding to the same site as allosteric antagonists.

Demange Luc, Boeglin Damien, Moulin Aline, Mousseaux Delphine, Ryan Joanne, Bergé Gilbert, Gagne Didier, Heitz Annie, Perrissoud Daniel, Locatelli Vittorio, Torsello Antonio, Galleyrand Jean-Claude, Fehrentz Jean-Alain, Martinez Jean (2007). Synthesis and Pharmacological in vitro and in vivo : Evaluations of Novel Triazole Derivatives as Ligands of the Ghrelin Receptor 1. J. Med. Chem. 50 :1939-57. Institut Max Mousseron, équipe JA Fehrentz

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